The world’s population over 60 years of age , which has increased sixfold in six decades, accounts for 27 % of total consumption , a figure that represents four trillion dollars.
New NAD+ supplements arrive on the market to promote healthy aging
Madrid , February 19 , 2026. Nanotechnology , cell reprogramming , and gene therapies were presented as the main avenues of research to curb the impact of neurodegenerative diseases on the second day of the Longevity World Forum , the global summit on aging , whose fourth edition is taking place from February 18 to 20 , 2026 , at La Nave (Madrid) . The sessions also included several presentations on nutrition and next – generation nutritional supplements such as NAD+.
“ Nanotechnology is already solving problems in neurodegenerative diseases ,” stated Valle Palomo , director of the Biosensors in Neuroscience Laboratory at IMDEA Neuroscience . The chemist explained that one of the main drawbacks of drugs for these pathologies is the difficulty in reaching the brain because they cannot cross the blood – brain barrier . “ Some nanotechnology – based solutions have already been presented to overcome this barrier and also to develop sensors that can diagnose these diseases early , ” she specified .
NAD+ precursors
Furthermore , Stephan Christen, a metabolic researcher at Nestlé Research, presented a study published in the latest issue of Nature Metabolism on the impact of two weeks of supplementation with three NAD + precursors in healthy adults . Christen also explained the relationship between mitochondrial dysfunction and inflammation , aging , and oxidative stress . “ NAD molecules have repercussions on multiple functions : energy metabolism , circadian rhythm , DNA repair, mitochondrial functions, and chronic inflammation, ” he noted .
One of the most innovative formulas in supplementation has been introduced by Klok Longevity, which features the first NAD precursor in liquid gel format , combining six synergistic ingredients ( calcium alpha – ketoglutarate , liposomal NAD, quercetin , L- arginine , resveratrol , and rhodiola). Meanwhile , Solgar® – Cellular Energy – NAD+ Precursor is an advanced formulation supplement with nicotinamide riboside chloride ( NIAGEN® ) , an NAD+ precursor and source of niacin ( vitamin B3 ) , an essential nutrient that our cells need to produce energy and maintain an active metabolism . It also contains vitamins B12 and C.
Gene therapy for frailty and Alzheimer’s
Meanwhile , Cristina Sánchez Puelles , a researcher at Tetraneuron , presented a gene therapy for frailty and Alzheimer’s disease , which is about to be used in patients . ” We have already finished the preclinical studies and are in the patient recruitment phase ,” she pointed out . Regarding cell reprogramming , Jean-Marc Lemaitre, research director at INSERM and co- founder and co – director of the Institute of Regenerative Medicine and Biotherapies ( IRMB ) , stated emphatically : ” A single early reprogramming can prevent osteoarthritis in later life . “
In other news , Débora Bueno, director of the Longevity and Microbiota Unit at Olympia, part of the Quirón Salud Group, advocated for personalized recommendations for patients . “ We must interpret what we see in the microbiota test in conjunction with the patient’s medical history and lifestyle . Limiting the microbiota to the digestive system is only seeing the tip of the iceberg and its true role in health , ” she commented .
The second day opened with a presentation by Pedro Ros , founder of SilverEconomy.com , who offered a global overview of consumer trends among those over 60 and the demographic evolution this age group has experienced in the last six decades . “ Life expectancy has increased by more than 20 years since I ‘ve been around . Currently , there are more than 1.2 billion people over 60 , whereas in the 1960s there were 200 million , ” he commented . He also highlighted the so – called ‘ silver generation , ‘ which represents 15 % of the population but accounts for 27 % of total consumption . “ This age group , living in the most developed and wealthy countries , spends more than four trillion dollars on goods and services . In the case of health , those under 60 spend less than 9 % of their budget in this sector , but from that age onwards the figure increases to ” 14% , mainly due to dental , vision and hearing expenses , ” he noted .
Longevity startup competition
The final day will focus on longevity entrepreneurship , featuring the first edition of a startup competition where eight companies will present their pitches in elevator format . Two winners will be chosen from among them : the Best Longevity Pitch Award and the Longevity Potential Award .
The sessions will be completed with a talk on longevity entrepreneurship by Leslie Kenny, from Oxford Healthspan ; and a round table discussion with Manuel Pérez Alonso, founding partner and scientific consultant of Mendel Brain; Carolina Hernández, founder and CEO of Longevity Zone; and Ricardo Álvarez , director of corporate partnerships for Spain and Portugal at Plug &Play .
More information : www.longevityworldforum.com
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